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Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses.
- Source :
-
Nutrients [Nutrients] 2021 Jun 08; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 08. - Publication Year :
- 2021
-
Abstract
- Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in several body fluids. The effects of this exposure on the fetus are under active investigation in several research laboratories. The aim of our work was to study the impact of prenatal exposure to BPA in the liver of rat fetuses from a sex-dependent point of view. We particularly investigated the effects of prenatal BPA exposure on hepatic lipids because of their crucial role, not only for the liver, but also for the whole-body functions. Our results demonstrate that the liver of rat fetuses, in utero exposed to a very low dose of BPA (2.5 µg/kg/day), displays significant modulations with regard to proteins involved in cholesterol and fatty acid biosynthesis and trafficking. Moreover, an impact on inflammatory process has been observed. All these effects are dependent on sex, being observable only in female rat fetuses. In conclusion, this work demonstrates that maternal exposure to BPA compromises hepatic lipid metabolism in female offspring, and it also reveals the perspective impact of BPA on human health at doses currently considered safe.
- Subjects :
- Animals
Benzhydryl Compounds chemistry
Estrogen Receptor alpha metabolism
Female
Fetus drug effects
Inflammation pathology
Lipids blood
Liver drug effects
Liver enzymology
Male
Phenols chemistry
Pregnancy
Rats, Sprague-Dawley
Rats
Benzhydryl Compounds toxicity
Fetus metabolism
Lipid Metabolism drug effects
Liver metabolism
Phenols toxicity
Prenatal Exposure Delayed Effects metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 34201166
- Full Text :
- https://doi.org/10.3390/nu13061970