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Determinants of Prognosis in Triple-Negative Breast Cancer: Report from a Large Breast Cancer Registry.
- Source :
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Archives of Iranian medicine [Arch Iran Med] 2021 Apr 01; Vol. 24 (4), pp. 280-288. Date of Electronic Publication: 2021 Apr 01. - Publication Year :
- 2021
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Abstract
- Background: The outcome of patients with triple-negative breast cancer (TNBC) is highly dependent on demographic factors and ethnicity. We aimed to evaluate the clinicopathological determinants of prognosis among women with TNBC using data from one of the largest breast cancer (BC) registries.<br />Methods: A total of 6145 patients with BC from our referral center were evaluated from 1995 to 2018, among whom 523 had TNBC. The baseline, menstrual and reproductive, treatment and pathology related characteristics were evaluated.<br />Results: Among TNBC patients, the rate of stage 3 and 4 BC (29.9% vs. 14.4% and 7.8% vs. 0% for stage 3 and 4, respectively; P <0.001), invasive ductal carcinoma (90.7% vs. 75.6%; P =0.004), nodal involvement (46.7% vs. 33.4%; P =0.026), mastectomy (57.3% vs. 37.8%; P =0.001) and axillary node dissection (76.7% vs. 59.8%; P =0.019) was significantly higher in the group that developed recurrence. Disease-free-survival was 80.6% (157.76 ± 9.48 months) and overall-survival was 90.1% (182.73 ± 3.28 months). For death, stage 3 BC (compared to stages 0 and 1 as base) showed a higher risk of earlier death (adjusted HR: 4.191, 95% CI=1.392-12.621; P =0.011). For recurrence, stage 3 BC (adjusted HR: 1.044, 95% CI=1.209-6.673; P =0.017) (compared to stages 0 and 1 as base) showed significantly higher risk for developing earlier recurrence. Moreover, those who had invasive ductal carcinoma (compared to other types of BCs) had a higher risk for developing earlier recurrence (adjusted HR: 3.307, 95% CI=1.191-0.724; P =0.012).<br />Conclusion: BC stage plays a significant role in both earlier recurrence and earlier mortality among patients with TNBC.<br /> (© 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
- Subjects :
- Breast pathology
Female
Humans
Mastectomy
Neoplasm Recurrence, Local epidemiology
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Prognosis
Registries
Retrospective Studies
Breast Neoplasms epidemiology
Breast Neoplasms pathology
Carcinoma, Ductal, Breast epidemiology
Carcinoma, Ductal, Breast pathology
Triple Negative Breast Neoplasms epidemiology
Triple Negative Breast Neoplasms pathology
Triple Negative Breast Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1735-3947
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of Iranian medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34196187
- Full Text :
- https://doi.org/10.34172/aim.2021.39