Back to Search Start Over

Multistage Adaptive Nanoparticle Overcomes Biological Barriers for Effective Chemotherapy.

Authors :
Wang Y
Zhang Z
Zheng C
Zhao X
Zheng Y
Liu Q
Liu Y
Shi L
Source :
Small (Weinheim an der Bergstrasse, Germany) [Small] 2021 Aug; Vol. 17 (31), pp. e2100578. Date of Electronic Publication: 2021 Jun 30.
Publication Year :
2021

Abstract

Drug delivery systems (DDS) are extensively studied to improve the solubility, stability, pharmacokinetic, and biodistribution of chemotherapeutics. However, the drug delivery efficiency of traditional DDS is often limited by the complicated biological barriers in vivo. Herein, a multistage adaptive nanoparticle (MAN) that simultaneously overcomes multiple biological barriers to achieve tumor-targeted drug delivery with high efficiency is presented. MAN has a core-shell structure, in which both the core and the shell are made of responsive polymers. This structure allows MAN to present different surface properties to adapt to its surrounding biological microenvironment, thereby achieving enhanced stability in blood circulation, improved tumor accumulation and cellular internalization in tumor tissues, and effective release of drug in cells. With these unique characteristics, the MAN loaded with docetaxel achieves effective tumor suppression with reduced systemic toxicity. Furthermore, MAN can load almost any hydrophobic drugs, providing a general strategy for the tumor-targeted delivery of hydrophobic drugs to overcome the multiple biological barriers and improve the efficacy of chemotherapy.<br /> (© 2021 Wiley-VCH GmbH.)

Details

Language :
English
ISSN :
1613-6829
Volume :
17
Issue :
31
Database :
MEDLINE
Journal :
Small (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
34190401
Full Text :
https://doi.org/10.1002/smll.202100578