IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis.

Authors :: Turnbull IR
Mazer MB
Hoofnagle MH
Kirby JP
Leonard JM
Mejia-Chew C
Spec A
Blood J
Miles SM
Ransom EM
Potter RF
Gaut JP
Remy KE
Hotchkiss RS
Source :: Open forum infectious diseases [Open Forum Infect Dis] 2021 May 23; Vol. 8 (6), pp. ofab256. Date of Electronic Publication: 2021 May 23 (Print Publication: 2021).
Publication Year :: 2021
Abstract: A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii , Fusarium , and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

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