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Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis.
- Source :
-
Scientific reports [Sci Rep] 2021 Jun 29; Vol. 11 (1), pp. 13450. Date of Electronic Publication: 2021 Jun 29. - Publication Year :
- 2021
-
Abstract
- Atherosclerosis has been considered as the main cause of morbidity, mortality, and disability worldwide. The first screening for antigen markers was conducted using the serological identification of antigens by recombinant cDNA expression cloning, which has identified adaptor-related protein complex 3 subunit delta 1 (AP3D1) as an antigen recognized by serum IgG antibodies of patients with atherosclerosis. Serum antibody levels were examined using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) using a recombinant protein as an antigen. It was determined that the serum antibody levels against AP3D1 were higher in patients with acute ischemic stroke (AIS), transient ischemic attack, diabetes mellitus (DM), cardiovascular disease, chronic kidney disease (CKD), esophageal squamous cell carcinoma (ESCC), and colorectal carcinoma than those in the healthy donors. The area under the curve values of DM, nephrosclerosis type of CKD, and ESCC calculated using receiver operating characteristic curve analysis were higher than those of other diseases. Correlation analysis showed that the anti-AP3D1 antibody levels were highly associated with maximum intima-media thickness, which indicates that this marker reflected the development of atherosclerosis. The results of the Japan Public Health Center-based Prospective Study indicated that this antibody marker is deemed useful as risk factors for AIS.
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Risk Factors
Adaptor Protein Complex 3 blood
Adaptor Protein Complex 3 immunology
Adaptor Protein Complex delta Subunits blood
Adaptor Protein Complex delta Subunits immunology
Atherosclerosis blood
Atherosclerosis complications
Atherosclerosis immunology
Autoantibodies blood
Autoantibodies immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Ischemic Stroke blood
Ischemic Stroke etiology
Ischemic Stroke immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34188129
- Full Text :
- https://doi.org/10.1038/s41598-021-92786-9