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Elucidation of spleen elasticity and viscosity in a carbon tetrachloride rat model of liver cirrhosis using a new ultrasound elastography.
- Source :
-
Journal of medical ultrasonics (2001) [J Med Ultrason (2001)] 2021 Oct; Vol. 48 (4), pp. 431-437. Date of Electronic Publication: 2021 Jun 29. - Publication Year :
- 2021
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Abstract
- Purpose: Measurement of spleen stiffness (SS) using ultrasound (US) elastography is useful for predicting portal hypertension. However, the mechanism leading to increased SS remains unclear. We jointly developed a new US elastography system (Aplio i-series, Canon Medical Systems) that can easily measure organ viscosity (dispersion slope: DS). We analyzed the cause of increased SS by calculating the shear wave speed (SWs, which reflects fibrosis) and DS of the spleen in carbon tetrachloride (CCL <subscript>4</subscript> ) rat liver cirrhosis models.<br />Methods: A total of 13 Sprague-Dawley rats were randomly divided into four groups (C group: 3 rats as control, 2D group: 3 rats injected with CCL <subscript>4</subscript> twice in 1 week, 4D group: 4 rats injected 4 times in 1 week, 6W group: 3 rats injected twice a week for 6 weeks). The SWs and the DS of each group were calculated, and histopathological analysis was performed.<br />Results: The spleen SWs of the 6W group was significantly higher than that of the C group (p = 0.044). The spleen DS did not change after CCL <subscript>4</subscript> . The liver SWs of the 4D and 6W groups was significantly higher than that of the C group (p = 0.012 and 0.007, respectively) with fibrosis change on histopathology, and the DS of the 4D group was significantly higher than that of the C group (p = 0.033). Splenic fibrosis was confirmed in the 6W group, but inflammation and necrosis were not seen.<br />Conclusion: SS increased due to fibrosis and can be predicted based on SWs and DS values.<br /> (© 2021. The Japan Society of Ultrasonics in Medicine.)
Details
- Language :
- English
- ISSN :
- 1613-2254
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medical ultrasonics (2001)
- Publication Type :
- Academic Journal
- Accession number :
- 34185192
- Full Text :
- https://doi.org/10.1007/s10396-021-01110-5