Back to Search
Start Over
Antibiofilm activity of host defence peptides: complexity provides opportunities.
- Source :
-
Nature reviews. Microbiology [Nat Rev Microbiol] 2021 Dec; Vol. 19 (12), pp. 786-797. Date of Electronic Publication: 2021 Jun 28. - Publication Year :
- 2021
-
Abstract
- Host defence peptides (HDPs) are integral components of innate immunity across all living organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells (referred to as antimicrobial peptides), and exhibit antibiofilm (referred to as antibiofilm peptides), antiviral, antifungal and host-directed immunomodulatory activities. In this Review, we discuss how the complex functional attributes of HDPs provide many opportunities for the development of antimicrobial therapeutics, focusing particularly on their emerging antibiofilm properties. The mechanisms of action of antibiofilm peptides are compared and contrasted with those of antimicrobial peptides. Furthermore, obstacles for the practical translation of candidate peptides into therapeutics and the potential solutions are discussed. Critically, HDPs have the value-added assets of complex functional attributes, particularly antibiofilm and anti-inflammatory activities and their synergy with conventional antibiotics.<br /> (© 2021. Springer Nature Limited.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Anti-Infective Agents chemistry
Anti-Inflammatory Agents chemistry
Antifungal Agents chemistry
Antifungal Agents pharmacology
Antimicrobial Cationic Peptides chemistry
Antimicrobial Peptides chemistry
Antiviral Agents chemistry
Antiviral Agents pharmacology
Immunity, Innate
Immunomodulating Agents chemistry
Anti-Infective Agents pharmacology
Anti-Inflammatory Agents pharmacology
Antimicrobial Cationic Peptides pharmacology
Antimicrobial Peptides pharmacology
Biofilms drug effects
Immunomodulating Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1740-1534
- Volume :
- 19
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature reviews. Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 34183822
- Full Text :
- https://doi.org/10.1038/s41579-021-00585-w