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Serological response to COVID-19 vaccination in patients with cancer older than 80 years.
- Source :
-
Journal of geriatric oncology [J Geriatr Oncol] 2021 Nov; Vol. 12 (8), pp. 1253-1255. Date of Electronic Publication: 2021 Jun 11. - Publication Year :
- 2021
-
Abstract
- Central studies carried out on vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-COV2) excluded patients receiving immunosuppressive therapy and those diagnosed with an immunosuppressive condition. Moreover, there are no data on vaccine efficacy regarding older patients with cancer.<br />Objectives: The primary objective was to evaluate the seroprevalence of the SARS-CoV2 IgG in older patients (aged ≥80 years) diagnosed with solid or hematological malignancies, one month after administering the second dose of the BNT162b2 vaccine.<br />Materials and Methods: We screened 74 older patients with cancer, 45 of them accepted to receive the vaccination and collected serum samples from 36 patients; a group of medical doctors and nurses from our hospital was used as a control in a 1:2 ratio.<br />Results: The median age was 82 years (range 80-89). Median serum IgG were 2396,10 AU/ml (range 0-32,763,00) in patients with cancer and 8737,49 AU/ml (398.90-976,280,00) in the control group, p < 0.0001. Additional subgroup analyses were performed comparing males and females, patients treated with chemotherapy versus other therapies (immunotherapy, targeted therapy), solid tumors versus hematological malignancies, early (I-II) versus advanced (III-IV) stage of disease, continuative corticosteroid use or not. None of them reached statistical significance.<br />Conclusion: Our study shows for the first time that patients with cancer aged ≥80 years can have a serological response to the BNT162b2 COVID-19 vaccine one month after vaccination and consequently support the vaccination campaign currently underway in this frail population.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-4076
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of geriatric oncology
- Publication Type :
- Editorial & Opinion
- Accession number :
- 34175246
- Full Text :
- https://doi.org/10.1016/j.jgo.2021.06.002