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Nanoaggregate-forming lipid-conjugated AS1411 aptamer as a promising tumor-targeted delivery system of anticancer agents in vitro.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2021 Aug; Vol. 36, pp. 102429. Date of Electronic Publication: 2021 Jun 24. - Publication Year :
- 2021
-
Abstract
- Nanoparticles offer targeted delivery of drugs with minimal toxicity to surrounding healthy tissue and have great potential in the management of human papillomavirus (HPV)-related diseases. We synthesized lipid-modified AS1411 aptamers capable of forming nanoaggregates in solution containing Mg <superscript>2+</superscript> . The nanoaggregates presented suitable properties for pharmaceutical applications such as small size (100 nm), negative charge, and drug release. The nanoaggregates were loaded with acridine orange derivative C <subscript>8</subscript> for its specific delivery into cervical cancer cell lines and HPV-positive tissue biopsies. This improved inhibition of HeLa proliferation and cell uptake without significantly affecting healthy cells. Finally, the nanoaggregates were incorporated in a gel formulation with promising tissue retention properties aiming at developing a local delivery strategy of the nanoaggregates in the female genital tract. Collectively, these findings suggest that the nanoformulation protocol has great potential for the delivery of both anticancer and antiviral agents, becoming a novel modality for cervical cancer management.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Female
HeLa Cells
Humans
Uterine Cervical Neoplasms metabolism
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents pharmacology
Antiviral Agents chemistry
Antiviral Agents pharmacokinetics
Antiviral Agents pharmacology
Aptamers, Nucleotide chemistry
Aptamers, Nucleotide pharmacokinetics
Aptamers, Nucleotide pharmacology
Cell Proliferation drug effects
Drug Delivery Systems
Oligodeoxyribonucleotides chemistry
Oligodeoxyribonucleotides pharmacokinetics
Oligodeoxyribonucleotides pharmacology
Uterine Cervical Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 36
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34174419
- Full Text :
- https://doi.org/10.1016/j.nano.2021.102429