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The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl 4 -induced liver injury in vivo.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 338-349. Date of Electronic Publication: 2021 Jun 24. - Publication Year :
- 2021
-
Abstract
- Chemical liver injury threatens seriously human health, along with the shortage of efficiency and low-toxicity drugs. Herein, the novel oral nanocomplexes composed of deoxycholic acid-grafted chitosan and oleanolic acid were constructed to reverse the CCl <subscript>4</subscript> -induced acute liver damage in mice. Results indicated core-shell nanocomplexes, maintained by the hydrophobic interaction between deoxycholic acid and oleanolic acid, could be dissociated in the intestine. Notably, the nanocomplexes possessed superior hepatoprotective effect in vivo, possibly due to the synergistic effect between grafted chitosan and oleanolic acid. Mechanism investigations suggested that nanocomplexes reversed CCl <subscript>4</subscript> -induced liver injury through improving hepatic antioxidant capacity via NrF2/Keap1 pathway and regulating inflammation response via NF-κB signaling pathway. The novel oral nanocomplexes represent an effective strategy for chemical liver injury therapy.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Biological Availability
Chemical and Drug Induced Liver Injury genetics
Chemical and Drug Induced Liver Injury metabolism
Gene Expression Regulation drug effects
Humans
Male
Mice
NF-kappa B genetics
NF-kappa B metabolism
Nanocomposites
Oleanolic Acid chemistry
Oleanolic Acid pharmacokinetics
Oxidative Stress drug effects
Signal Transduction drug effects
Carbon Tetrachloride toxicity
Chemical and Drug Induced Liver Injury prevention & control
Chitosan chemistry
Deoxycholic Acid chemistry
Oleanolic Acid administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 185
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 34171250
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2021.06.109