NADPH is important for isobutanol tolerance in a minimal medium of Saccharomyces cerevisiae.

Authors :: Yoshikawa Y
Nasuno R
Takagi H
Source :: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Aug 25; Vol. 85 (9), pp. 2084-2088.
Publication Year :: 2021
Abstract: We showed that the isobutanol sensitivity in glucose-6-phosphate dehydrogenase-deficient cells of the yeast Saccharomyces cerevisiae was rescued by an alternative NADPH producer, acetaldehyde dehydrogenase, but not in the cells lacking 6-phosphogluconate dehydrogenase. This phenotype correlated with the intracellular NADPH/NADP+ ratio in yeast strains. Our findings indicate the importance of NADPH for the isobutanol tolerance of yeast cells.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)

Subjects :: Acetaldehyde metabolism
Aldehyde Oxidoreductases metabolism
Culture Media
Fermentation
Glucose-6-Phosphate metabolism
Phosphogluconate Dehydrogenase metabolism
Saccharomyces cerevisiae enzymology
Butanols metabolism
NADP metabolism
Saccharomyces cerevisiae metabolism

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