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Hepatoxicity Induced by Clozapine: Case Report and Brief Review.
- Source :
-
Revista Colombiana de psiquiatria (English ed.) [Rev Colomb Psiquiatr (Engl Ed)] 2021 Jun 08. Date of Electronic Publication: 2021 Jun 08. - Publication Year :
- 2021
- Publisher :
- Ahead of Print
-
Abstract
- Introduction: Antipsychotics are drugs that can produce transient elevations of hepatic enzymes. Clozapine is an atypical antipsychotic used in treatment-resistant schizophrenia and there is evidence that it can produce elevations of hepatic transaminases, expression of liver damage in a hepatocellular pattern.<br />Methods: Case report and non-systematic review of the relevant literature.<br />Case Presentation: A 39-year-old woman with a diagnosis of paranoid schizophrenia attended the emergency department of a general hospital for nausea, vomiting and jaundice that appeared after the initiation of clozapine. There was no clinical improvement during hospitalisation, and death occurred after 44 days.<br />Literature Review: Clozapine can increase the liver enzyme levels transiently and asymptomatically; however, there are clinical criteria that recommend the withdrawal of the antipsychotic.<br />Conclusions: This is the third case reported in the literature of a fatal outcome of clozapine-induced hepatotoxicity.<br /> (Copyright © 2021 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España, S.L.U. All rights reserved.)
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 2530-3120
- Database :
- MEDLINE
- Journal :
- Revista Colombiana de psiquiatria (English ed.)
- Publication Type :
- Report
- Accession number :
- 34167791
- Full Text :
- https://doi.org/10.1016/j.rcp.2021.04.010