Back to Search
Start Over
Caloric restriction disrupts the microbiota and colonization resistance.
- Source :
-
Nature [Nature] 2021 Jul; Vol. 595 (7866), pp. 272-277. Date of Electronic Publication: 2021 Jun 23. - Publication Year :
- 2021
-
Abstract
- Diet is a major factor that shapes the gut microbiome <superscript>1</superscript> , but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet (NCT01105143). Although metabolic health was improved, severe calorie restriction led to a decrease in bacterial abundance and restructuring of the gut microbiome. Transplantation of post-diet microbiota to mice decreased their body weight and adiposity relative to mice that received pre-diet microbiota. Weight loss was associated with impaired nutrient absorption and enrichment in Clostridioides difficile, which was consistent with a decrease in bile acids and was sufficient to replicate metabolic phenotypes in mice in a toxin-dependent manner. These results emphasize the importance of diet-microbiome interactions in modulating host energy balance and the need to understand the role of diet in the interplay between pathogenic and beneficial symbionts.
- Subjects :
- Adiposity
Animals
Bacteria growth & development
Bacteria pathogenicity
Bacterial Toxins metabolism
Bile Acids and Salts metabolism
Body Weight
Clostridioides difficile growth & development
Clostridioides difficile isolation & purification
Clostridioides difficile metabolism
Energy Metabolism
Humans
Intestinal Absorption
Male
Mice
Nutrients metabolism
Symbiosis
Weight Loss
Bacteria isolation & purification
Bacteria metabolism
Caloric Restriction
Diet, Reducing
Gastrointestinal Microbiome physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 595
- Issue :
- 7866
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 34163067
- Full Text :
- https://doi.org/10.1038/s41586-021-03663-4