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Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma.
- Source :
-
Scientific reports [Sci Rep] 2021 Jun 23; Vol. 11 (1), pp. 13192. Date of Electronic Publication: 2021 Jun 23. - Publication Year :
- 2021
-
Abstract
- Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Here we show HNcSCC with extensive PNI demonstrates significant up- and down-regulation of 144 genes associated with extracellular matrix interactions, epithelial to mesenchymal transition, cell adhesion, cellular motility, angiogenesis, and cellular differentiation. Gene expression of focal and non PNI cohorts were indistinguishable and were combined for further analyses. There is clinicopathological correlation between gene expression analysis findings and disease behaviour and a tailored panel of 10 genes was able to identify extensive PNI with 96% sensitivity and 95% specificity.
- Subjects :
- Aged
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Female
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms mortality
Head and Neck Neoplasms pathology
Humans
Male
Neoplasm Invasiveness genetics
Neoplasm Proteins biosynthesis
Neoplasm Proteins genetics
Peripheral Nerves pathology
RNA, Messenger biosynthesis
RNA, Messenger genetics
RNA, Neoplasm biosynthesis
RNA, Neoplasm genetics
Sensitivity and Specificity
Squamous Cell Carcinoma of Head and Neck metabolism
Squamous Cell Carcinoma of Head and Neck mortality
Squamous Cell Carcinoma of Head and Neck pathology
Carcinoma, Squamous Cell genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms genetics
Squamous Cell Carcinoma of Head and Neck genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34162930
- Full Text :
- https://doi.org/10.1038/s41598-021-92335-4