Back to Search
Start Over
Plant derived cyclic peptides.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2021 Jun 30; Vol. 49 (3), pp. 1279-1285. - Publication Year :
- 2021
-
Abstract
- Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years. Several gene sequences for plant cyclic peptides have been discovered over the last two decades but it is only recently that we are beginning to understand the intricacies associated with their biosynthesis. Recent studies have focussed on three main classes of plant derived cyclic peptides, namely orbitides, SFTI related peptides and cyclotides. In this mini-review, we discuss the expansion of the known sequence and structural diversity in these families, insights into the enzymes involved in the biosynthesis, the exciting applications which includes a cyclotide currently in clinical trials for the treatment of multiple sclerosis, and new production methods that are being developed to realise the potential of plant cyclic peptides as pharmaceutical or agricultural agents.<br /> (© 2021 The Author(s).)
- Subjects :
- Animals
Cyclotides chemistry
Cyclotides pharmacology
Cysteine Endopeptidases metabolism
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental drug therapy
Humans
Multiple Sclerosis drug therapy
Peptides, Cyclic chemistry
Peptides, Cyclic pharmacology
Plant Proteins chemistry
Plant Proteins pharmacology
Protein Precursors chemistry
Protein Precursors metabolism
Cyclotides metabolism
Peptides, Cyclic metabolism
Plant Proteins metabolism
Plants metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 34156400
- Full Text :
- https://doi.org/10.1042/BST20200881