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Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
- Source :
-
Archives of virology [Arch Virol] 1988; Vol. 101 (1-2), pp. 1-12. - Publication Year :
- 1988
-
Abstract
- The potential of utilizing a radio-labelled derivative of the antiviral drug (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) for the specific, non-invasive, in vivo diagnosis of Herpes simplex virus encephalitis (HSVE) was investigated in a rat model of the disease. Following pharmacological disruption of the blood brain barrier radiolabelled IVDU was administered by intra-carotid injection. Brain radioactivity was compared between control and infected animals via gamma camera scintigraphy. After clearance of non-metabolized drug, markedly higher levels of activity were found in infected brain. Post-mortem studies of cryostat sections of brain examined by autoradiography and immunochemical staining showed the radioactivity selectively accumulated in areas of virus infection. These results indicate that radio-labelled derivatives of antiviral drugs may allow the specific neuro-radiological diagnosis of HSVE.
- Subjects :
- Animals
Autoradiography
Blood-Brain Barrier drug effects
Brain metabolism
Carotid Arteries
Encephalitis microbiology
Etoposide pharmacology
Female
Idoxuridine administration & dosage
Idoxuridine pharmacokinetics
Injections, Intra-Arterial
Iodine Radioisotopes
Isotope Labeling methods
Radionuclide Imaging
Rats
Vero Cells
Antiviral Agents administration & dosage
Antiviral Agents pharmacokinetics
Encephalitis diagnostic imaging
Herpes Simplex diagnostic imaging
Idoxuridine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0304-8608
- Volume :
- 101
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 3415476
- Full Text :
- https://doi.org/10.1007/BF01314647