Back to Search
Start Over
Ultrasound Doppler enthesitis shows sensitivity to change after biological therapy in spondyloarthritis and psoriatic arthritis patients.
- Source :
-
Scandinavian journal of rheumatology [Scand J Rheumatol] 2022 May; Vol. 51 (3), pp. 196-204. Date of Electronic Publication: 2021 Jun 21. - Publication Year :
- 2022
-
Abstract
- Objective: To explore the sensitivity to change in power Doppler (PD) enthesitis in active spondyloarthritis (SpA) and psoriatic arthritis (PsA) patients.<br />Method: This was a longitudinal study in patients with SpA and PsA with active disease [patients starting or switching to biological disease-modifying anti-rheumatic drugs (bDMARDs)]. The MAdrid Sonographic Enthesitis Index (MASEI) was performed at baseline and at 3 and 6 month visits. The MASEI and Outcome Measures in Rheumatology (OMERACT) PD enthesitis definitions were checked. Reliability analysis among three readers was performed with ultrasound (US)-recorded videos.<br />Results: US examinations of 25 patients were included; 16 (64%) had SpA and nine (36%) PsA. The median (interquartile range, IQR) age was 49 (41-61) years, and 13 patients (52%) were female. The median (IQR) 28-joint Disease Activity Score of 3.6 (2.3-4.2), Bath Ankylosing Spondylitis Disease Activity Index of 6.7 (6.1-7.4), and C-reactive protein value of 8.2 (1.6-20) reflected moderate to high disease activity at baseline. Both MASEI and OMERACT PD enthesitis improved significantly at 3 and 6 month follow-up (p < 0.05) and showed sensitivity to change (standard error of measurement = 0.47 and 0.61, respectively). Improvement in clinical activity outcomes was significantly associated with decreases in MASEI and OMERACT PD enthesitis counts (p < 0.05). The MASEI and OMERACT PD definitions had excellent reliability (kappa = 0.918 and 0.865, respectively).<br />Conclusion: PD enthesitis significantly improved at 3 and 6 month follow-up in patients undergoing bDMARD therapy. Both MASEI and OMERACT PD US enthesitis reflect response to treatment.
- Subjects :
- Adult
Biological Therapy
Female
Humans
Longitudinal Studies
Male
Middle Aged
Reproducibility of Results
Severity of Illness Index
Arthritis, Psoriatic complications
Arthritis, Psoriatic diagnostic imaging
Arthritis, Psoriatic drug therapy
Enthesopathy diagnostic imaging
Enthesopathy drug therapy
Spondylarthritis complications
Spondylarthritis diagnostic imaging
Spondylarthritis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7732
- Volume :
- 51
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 34152245
- Full Text :
- https://doi.org/10.1080/03009742.2021.1921348