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Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 82 (3), pp. 913-919. - Publication Year :
- 2021
-
Abstract
- Plasma neurofilament light chain (NfL) is a marker of neuronal damage in different neurological disorders and might predict disease progression in dementia with Lewy bodies (DLB). The study enrolled 45 controls and 44 DLB patients (including 17 prodromal cases) who underwent an extensive assessment at baseline and at 2 years follow-up. At baseline, plasma NfL levels were higher in both probable DLB and prodromal cases compared to controls. Plasma NfL emerged as the best predictor of cognitive decline compared to age, sex, and baseline severity variables. The study supports the role of plasma NfL as a useful prognostic biomarker from the early stages of DLB.
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Disease Progression
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Predictive Value of Tests
Cognitive Dysfunction blood
Cognitive Dysfunction diagnosis
Lewy Body Disease blood
Lewy Body Disease diagnosis
Neurofilament Proteins blood
Prodromal Symptoms
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Report
- Accession number :
- 34151807
- Full Text :
- https://doi.org/10.3233/JAD-210342