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Vascular Endothelial Galectins in Leukocyte Trafficking.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Jun 01; Vol. 12, pp. 687711. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Leukocyte recruitment to the site of injury is a crucial event in the regulation of an inflammatory response. Tight regulation of interactions between the endothelium and circulating leukocytes is necessary to ensure a protective response to injury does not result in inflammatory disease. Rising interest in the broad immunoregulatory roles displayed by members of the glycan-binding galectin family suggests that these proteins could be an attractive target for therapeutic intervention, since their expression is significantly altered in disease. The focus of this review is to summarize current knowledge on the role of galectins in leukocyte trafficking during inflammation and the clinical approaches being taken to target these interactions for treatment of inflammatory disease.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Lightfoot, McGettrick and Iqbal.)
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Endothelial Cells drug effects
Endothelial Cells immunology
Endothelium, Vascular drug effects
Endothelium, Vascular immunology
Galectins antagonists & inhibitors
Humans
Inflammation drug therapy
Inflammation immunology
Leukocytes drug effects
Leukocytes immunology
Signal Transduction
Cell Adhesion drug effects
Endothelial Cells metabolism
Endothelium, Vascular metabolism
Galectins metabolism
Inflammation metabolism
Leukocyte Rolling drug effects
Leukocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34140956
- Full Text :
- https://doi.org/10.3389/fimmu.2021.687711