Back to Search
Start Over
CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease.
- Source :
-
Blood [Blood] 2021 Nov 04; Vol. 138 (18), pp. 1727-1732. - Publication Year :
- 2021
-
Abstract
- Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune function and proinflammation. Low-grade inflammation has been implicated in the pathogenesis of osteoarthritis (OA), the main indication for total hip arthroplasty (THA). THA-derived hip bones serve as a major source of healthy hematopoietic cells in experimental hematology. We prospectively investigated frequency and clinical associations of CH in 200 patients without known hematologic disease who were undergoing THA. Prevalence of CH was 50%, including 77 patients with CH of indeterminate potential (CHIP, defined as somatic variant allele frequencies [VAFs] ≥2%), and 23 patients harboring CH with lower mutation burden (VAF, 1% to 2%). Most commonly mutated genes were DNMT3A (29.5%), TET2 (15.0%), and ASXL1 (3.5%). CHIP is significantly associated with lower hemoglobin, higher mean corpuscular volume, previous or present malignant disease, and CVD. Strikingly, we observed a previously unreported association of CHIP with autoimmune diseases (AIDs; multivariable adjusted odds ratio, 6.6; 95% confidence interval, 1.7-30; P = .0081). These findings underscore the association between CH and inflammatory diseases. Our results have considerable relevance for managing patients with OA and AIDs or mild anemia and question the use of hip bone-derived cells as healthy experimental controls.<br /> (© 2021 by The American Society of Hematology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Autoimmune Diseases complications
Cells, Cultured
DNA Methyltransferase 3A genetics
DNA-Binding Proteins genetics
Dioxygenases genetics
Humans
Male
Middle Aged
Young Adult
Arthroplasty, Replacement, Hip
Autoimmune Diseases genetics
Clonal Hematopoiesis
Gene Frequency
Mutation
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 138
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 34139005
- Full Text :
- https://doi.org/10.1182/blood.2020010163