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Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Aug 03; Vol. 22 (15), pp. 2521-2525. Date of Electronic Publication: 2021 Jun 29. - Publication Year :
- 2021
-
Abstract
- Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing molecule-2 (CORM-2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Humans
Enzyme Inhibitors pharmacology
Enzyme Inhibitors chemistry
Prolyl-Hydroxylase Inhibitors pharmacology
Prolyl-Hydroxylase Inhibitors chemistry
Hypoxia-Inducible Factor-Proline Dioxygenases antagonists & inhibitors
Hypoxia-Inducible Factor-Proline Dioxygenases metabolism
Carbon Monoxide metabolism
Carbon Monoxide chemistry
Carbon Monoxide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 22
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 34137488
- Full Text :
- https://doi.org/10.1002/cbic.202100181