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Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria.

Authors :
Fajnzylber J
Sharaf R
Hutchinson JN
Aga E
Bosch RJ
Hartogensis W
Jacobson JM
Connick E
Volberding P
Skiest DJ
Margolis D
Sneller MC
Little SJ
Gulick RM
Mellors JW
Gandhi RT
Schooley RT
Henry K
Tebas P
Deeks S
Chun TW
Collier AC
Hecht FM
Li JZ
Source :
AIDS (London, England) [AIDS] 2021 Nov 01; Vol. 35 (13), pp. 2225-2227.
Publication Year :
2021

Abstract

Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.<br /> (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Details

Language :
English
ISSN :
1473-5571
Volume :
35
Issue :
13
Database :
MEDLINE
Journal :
AIDS (London, England)
Publication Type :
Report
Accession number :
34127579
Full Text :
https://doi.org/10.1097/QAD.0000000000002978