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Incidentally discovered myelolipomatous adrenal adenomas, including six cases presenting with hypercortisolism.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2021 Aug; Vol. 224, pp. 153508. Date of Electronic Publication: 2021 Jun 06. - Publication Year :
- 2021
-
Abstract
- Most adrenal incidentalomas are non-functioning adenomas that require no treatment. The presence of a myelolipomatous component of adrenal incidentalomas is a rare, but well-known occurrence in both hyperplastic and neoplastic lesions of the adrenal cortex. Although the improvements in abdominal imaging have increased identification of myelolipomatous adrenal cortical adenomas radiologically, due to the rarity of this lesion, the clinical pathological features of these lesions are unclear and can sometimes cause diagnostic difficulty. Eleven patients had surgeries at The University of Texas MD Anderson Cancer Center. Four additional cases were provided from an external collaborator. Of the 15 cases, there were 5 male and 10 female patients, with a median age of 52 years (mean 54 years, range 28-84 years). Clinical presentation included adrenal incidentaloma (n = 9), Cushing syndrome (n = 4, including 1 as a part of Carney complex), and subclinical Cushing syndrome (n = 2, including 1 with bilateral macronodular adrenal hyperplasia). In this study, we present the clinicopathologic features of fifteen myelolipomatous adrenal adenomas, the largest series published thus far.<br /> (Copyright © 2021 Elsevier GmbH. All rights reserved.)
- Subjects :
- Adenoma complications
Adenoma pathology
Adrenal Gland Neoplasms complications
Adrenal Gland Neoplasms pathology
Adult
Aged
Aged, 80 and over
Cushing Syndrome etiology
Cushing Syndrome pathology
Female
Humans
Hyperplasia complications
Hyperplasia diagnostic imaging
Hyperplasia pathology
Male
Middle Aged
Adenoma diagnostic imaging
Adrenal Gland Neoplasms diagnostic imaging
Cushing Syndrome diagnostic imaging
Incidental Findings
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 224
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 34119816
- Full Text :
- https://doi.org/10.1016/j.prp.2021.153508