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Phosphorylated xanthan gum-Ag(I) complex as antibacterial viscosity enhancer for eye drops formulation.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2021 Sep 01; Vol. 267, pp. 118196. Date of Electronic Publication: 2021 May 14. - Publication Year :
- 2021
-
Abstract
- Topical instillation of eye drops represents the treatment of choice for many ocular diseases. Ophthalmic formulations must meet general requirements, i.e. pH, osmolality, transparency and viscosity to ensure adequate retention without inducing irritation and the development of eye infections. We developed a phosphorylated xanthan gum-Ag(I) complex (XGP-Ag) showing pH (pH = 7.1 ± 0.3) and osmolality values (311 ± 2 mOsm/kg) close to that of human tears (pH = 6.5-7.6 and 304 ± 23 mOsm/kg) thanks to the presence of phosphate moieties along the chain. The presence of phosphate groups covalently bound to the XG chains avoids their dispersion in fluid, thus reducing the risk of corneal calcification. 0.02% w/v XGP-Ag solution showed high transparency (higher than 95% along the entire visible range), adequate refractive index (1.334 ± 0.001) and viscosity in the range: γ 1 s <superscript>-1</superscript> -10,000 s <superscript>- 1</superscript> (26.4 ± 0.8-2.1 ± 0.4 mPa·s). Its cytotoxicity and capability to hinder bacterial proliferation was also verified.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents toxicity
Coordination Complexes chemistry
Coordination Complexes toxicity
Humans
Mice
Microbial Sensitivity Tests
NIH 3T3 Cells
Ophthalmic Solutions chemistry
Ophthalmic Solutions toxicity
Organophosphates chemistry
Organophosphates pharmacology
Organophosphates toxicity
Phosphorylation
Polymers chemistry
Polymers pharmacology
Polymers toxicity
Polysaccharides, Bacterial chemistry
Polysaccharides, Bacterial toxicity
Pseudomonas fluorescens drug effects
Refractometry
Rheology
Silver chemistry
Silver toxicity
Staphylococcus epidermidis drug effects
Anti-Bacterial Agents pharmacology
Coordination Complexes pharmacology
Ophthalmic Solutions pharmacology
Polysaccharides, Bacterial pharmacology
Silver pharmacology
Viscosity drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 267
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 34119163
- Full Text :
- https://doi.org/10.1016/j.carbpol.2021.118196