Back to Search
Start Over
Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.
- Source :
-
Nature communications [Nat Commun] 2021 Jun 11; Vol. 12 (1), pp. 3554. Date of Electronic Publication: 2021 Jun 11. - Publication Year :
- 2021
-
Abstract
- Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.
- Subjects :
- Adult
Africa South of the Sahara epidemiology
Anti-Bacterial Agents administration & dosage
Antibodies blood
COVID-19 blood
COVID-19 epidemiology
Coinfection immunology
Cytokines blood
Dexamethasone administration & dosage
Female
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Male
Middle Aged
Pandemics
SARS-CoV-2 isolation & purification
COVID-19 Drug Treatment
COVID-19 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34117221
- Full Text :
- https://doi.org/10.1038/s41467-021-23267-w