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[The skin microbiome-useful for diagnosis and therapy?]

Authors :
Hülpüsch C
Reiger M
Source :
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete [Hautarzt] 2021 Jul; Vol. 72 (7), pp. 579-585. Date of Electronic Publication: 2021 Jun 11.
Publication Year :
2021

Abstract

Background: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors.<br />Aim: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed.<br />Materials and Methods: A literature search was performed.<br />Results: Several diseases are associated with negative alterations of the skin microbiome. In atopic dermatitis, a correlation between severity and increased availability of Staphylococcus aureus is known, with a loss of bacterial diversity on the skin. In the future, S. aureus will not only be used as a diagnostic marker in atopic dermatitis, but also represents a promising target as a predictive marker for therapeutic success. The role of the skin microbiome in psoriasis has not yet been researched in depth. However, there is evidence that dysbiosis of the skin microbiome contributes to the course of psoriasis and that there is a disturbance in immune tolerance in patients. In the case of acne, the involvement of Cutibacterium acnes in the clinical picture is well known; however, recent findings show that it is not sufficient to identify the species, but certain characteristics of C. acnes strains are associated.<br />Conclusion: Microbial biomarkers are currently only established in atopic dermatitis. For other diseases, this might be the case in the future; however combinations of microorganisms, single species and also strains with specific characteristics must be considered.

Details

Language :
German
ISSN :
1432-1173
Volume :
72
Issue :
7
Database :
MEDLINE
Journal :
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
Publication Type :
Academic Journal
Accession number :
34115159
Full Text :
https://doi.org/10.1007/s00105-021-04830-4