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Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.
- Source :
-
Ginekologia polska [Ginekol Pol] 2024; Vol. 95 (9), pp. 711-717. Date of Electronic Publication: 2021 Jun 09. - Publication Year :
- 2024
-
Abstract
- Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia.<br />Material and Methods: Nine pregnant women with early-onset severe preeclampsia (the study group) and 13 healthy pregnant women (the control group) were included in this study. The level of S100B in the amniotic fluid, maternal blood, and umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance imaging (SPRi) methods. Diagnostic values of S100B for early-onset severe preeclampsia were assessed by Receiver Operating Characteristic (ROC) curve analysis.<br />Results: The levels of S100B in maternal blood and amniotic fluid in the study group were higher than those in the control group (p < 0.05). ROC curve analysis showed that S100B detected by SPRi method (SPRi-S100B) showed a cut-off level of 181 ng/mL with sensitivity of 100%, a specificity of 84.6%, and a Youden index of 0.846 in the maternal blood, which had better clinical significance and diagnostic value (at than that detected by ELISA (ELISA-S100B).<br />Conclusions: The levels of S100B detected by SPRi in maternal blood can indicate early-onset severe preeclampsia and perinatal brain injury.
- Subjects :
- Humans
Female
Pregnancy
Adult
Biomarkers blood
Amniotic Fluid chemistry
Amniotic Fluid metabolism
Fetal Blood chemistry
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Sensitivity and Specificity
Clinical Relevance
Pre-Eclampsia blood
Pre-Eclampsia diagnosis
S100 Calcium Binding Protein beta Subunit blood
Subjects
Details
- Language :
- English
- ISSN :
- 2543-6767
- Volume :
- 95
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Ginekologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 34105751
- Full Text :
- https://doi.org/10.5603/GP.a2021.0126