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Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis?
- Source :
-
Reproductive biomedicine online [Reprod Biomed Online] 2021 Aug; Vol. 43 (2), pp. 319-328. Date of Electronic Publication: 2021 Apr 24. - Publication Year :
- 2021
-
Abstract
- Research Question: What is the potential role of immune cells and their inflammatory cytokines in the pathogenesis, development and establishment of endometriosis?<br />Design: Peritoneal fluid from 59 women (43 with endometriosis and 16 controls) who had undergone laparoscopic surgery was analysed. Changes in the population of innate and adaptive immune cells, cytokines, chemokines and growth factor expression were measured by flow cytometry, Luminex Technology and enzyme-linked immunosorbent assay.<br />Results: No differences were found in the frequencies of the innate and adaptive immune cells between women with and without endometriosis. In the peritoneal fluid of women with endometriosis, IL-1β, IL-1RN, IL-2, IL-4, IL-8, IL-10, IL-12 (p70), IL-17α, FGF2, G-CSF, MCP-1, MIP-1α and TNF-α were significantly increased compared with controls. A correlation between IL-2, MCP-1, MIP-1α, TNF-α and the severity of endometriosis was observed. The concentration of neopterin, a possible biomarker for this disease, was increased in women with endometriosis compared with controls.<br />Conclusions: The functional activity of immune cells seemed to be reduced despite their numbers remaining unchanged. The data indicate that a shift of T <subscript>H</subscript> cytokine profile occurs, which increases the T <subscript>H</subscript> 1-T <subscript>H</subscript> 2 ratio. This is driven by the increased levels of the cytokines (TNF-α and IL-2) in women with severe endometriosis.<br /> (Copyright © 2021. Published by Elsevier Ltd.)
- Subjects :
- Adolescent
Adult
Ascitic Fluid immunology
Ascitic Fluid metabolism
Ascitic Fluid pathology
Case-Control Studies
Chemokines metabolism
Cytokines metabolism
Endometriosis metabolism
Endometriosis pathology
Female
Humans
Intercellular Signaling Peptides and Proteins metabolism
Killer Cells, Natural pathology
Killer Cells, Natural physiology
Leukocytes pathology
Leukocytes physiology
Peritoneal Diseases metabolism
Peritoneal Diseases pathology
Signal Transduction immunology
Young Adult
Endometriosis immunology
Immune Tolerance physiology
Peritoneal Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1472-6491
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Reproductive biomedicine online
- Publication Type :
- Academic Journal
- Accession number :
- 34103260
- Full Text :
- https://doi.org/10.1016/j.rbmo.2021.04.012