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[Antiulcer activity of dibunol in experimental stomach and duodenal ulcers].
- Source :
-
Farmakologiia i toksikologiia [Farmakol Toksikol] 1988 May-Jun; Vol. 51 (3), pp. 60-4. - Publication Year :
- 1988
-
Abstract
- The antiulcer effect of two medicinal forms (oil solution, liniment) of dibunol in rats with different models of the stomach and duodenum ulcers was studied. The therapeutic activity of dibunol was evaluated by determining the index of ulcer formation as well as during the morphological and histochemical studies. The two medicinal forms of dibunol possessed equal antiulcer activity by all studied criteria. One should note a characteristic property of dibunol--its ability to produce pronounced epithelialization of ulceroerosive and ulceronecrotic lesions of the mucosa without rough scarring.
- Subjects :
- Animals
Anti-Ulcer Agents pharmacokinetics
Butylated Hydroxytoluene pharmacokinetics
Drug Evaluation, Preclinical
Duodenal Ulcer enzymology
Duodenal Ulcer pathology
Gastric Mucosa enzymology
Gastric Mucosa pathology
Histocytochemistry
Intestinal Mucosa enzymology
Intestinal Mucosa pathology
Liniments
Male
Rats
Rats, Inbred Strains
Solutions
Stomach Ulcer enzymology
Stomach Ulcer pathology
Time Factors
Anti-Ulcer Agents therapeutic use
Butylated Hydroxytoluene therapeutic use
Duodenal Ulcer drug therapy
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 0014-8318
- Volume :
- 51
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Farmakologiia i toksikologiia
- Publication Type :
- Academic Journal
- Accession number :
- 3410030