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The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
- Source :
-
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3328. Date of Electronic Publication: 2021 Jun 07. - Publication Year :
- 2021
-
Abstract
- Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.
- Subjects :
- Animals
Drosophila metabolism
Drosophila Proteins genetics
Drosophila melanogaster genetics
Ecdysone genetics
Epidermal Cells metabolism
Intercellular Signaling Peptides and Proteins
Larva metabolism
Metamorphosis, Biological
Morphogenesis genetics
Receptors, G-Protein-Coupled genetics
Relaxin metabolism
Drosophila Proteins metabolism
Drosophila melanogaster metabolism
Ecdysone pharmacology
Epidermis metabolism
Morphogenesis drug effects
Neurons metabolism
Receptors, G-Protein-Coupled metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34099654
- Full Text :
- https://doi.org/10.1038/s41467-021-23218-5