Back to Search
Start Over
Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Sep; Vol. 141, pp. 111793. Date of Electronic Publication: 2021 Jun 05. - Publication Year :
- 2021
-
Abstract
- Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there has no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through from anagen, catagen and telogen stages and are regulated by diverse signaling pathways, including Wnt/β-catenin, Notch, Epidermal growth factor (EGF) and Sonic hegehog (SHH). Wnt signals are essential for the initiation of hair follicle placode development and a new potential target of hair loss treatment. This study was designed to investigate the effect of liposomal honokiol (Lip-honokiol) on inducing hair anagen. We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection. We first demonstrated that Lip-Honokiol activated the Wnt3a/β-catenin pathway and downregulated the transforming growth factor-β1 (TGF-β1) to promote hair growth in mice via immunohistochemistry and immunofluorescence staining. These findings suggest that Lip-honokiol activated the Wnt/β-catenin pathway and accelerated the transfer from the telogen to anagen stage and finally promoted the hair growth.<br /> (Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Animals
Down-Regulation drug effects
Down-Regulation physiology
Female
Hair cytology
Hair drug effects
Hair metabolism
Hair Follicle cytology
Injections, Subcutaneous
Mice
Mice, Inbred C57BL
Signal Transduction drug effects
Signal Transduction physiology
Transforming Growth Factor beta1 antagonists & inhibitors
Biphenyl Compounds administration & dosage
Hair Follicle drug effects
Hair Follicle metabolism
Lignans administration & dosage
Transforming Growth Factor beta1 biosynthesis
Wnt3A Protein biosynthesis
beta Catenin biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 141
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 34098216
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111793