Color vision disturbances secondary to oral tranexamic acid.

Authors :: Kiser AS
Cooper GL
Napier JD
Howington GT
Source :: Journal of the American College of Emergency Physicians open [J Am Coll Emerg Physicians Open] 2021 May 29; Vol. 2 (3), pp. e12456. Date of Electronic Publication: 2021 May 29 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache, fatigue, cerebral thrombosis, dizziness, retinal artery occlusion, chromatopsia, and more. We present a case of acute color vision disturbance developed soon after initiation of oral TXA for epistaxis prophylaxis in the setting of factor VII deficiency. To our knowledge we report the only case of color vision disturbance in a pediatric patient and the only case after receiving oral TXA. Soon after discontinuing oral TXA the patient's altered perception of color vision resolved. The patient was subsequently discharged home with a prescription for an alternative antifibrinolytic (aminocaproic acid) and follow-up with neuro-ophthalmology.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2021 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.)