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Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin.
- Source :
-
Cell biochemistry and function [Cell Biochem Funct] 1988 Jul; Vol. 6 (3), pp. 191-5. - Publication Year :
- 1988
-
Abstract
- Luminol-dependent chemiluminescence of normal human monocytes activated by zymosan is demonstrated to be inhibited by tetrahydrobiopterin in a concentration-dependent manner. The reduced pterins tetrahydrobiopterin, dihydrobiopterin, and dihydroneopterin are all shown to be readily oxidized by the hydroxyl radical. The susceptibility of reduced pterins to free radical attack may explain the inhibition of chemiluminescence observed and an additional role of reduced pterins as free radical scavengers in tissues is considered.
- Subjects :
- Ascorbic Acid pharmacology
Biopterins blood
Biopterins pharmacology
Dithioerythritol pharmacology
Free Radicals
Humans
Hydrogen Peroxide
In Vitro Techniques
Luminescent Measurements
Macrophages drug effects
Macrophages metabolism
Monocytes metabolism
Neopterin analogs & derivatives
Oxidation-Reduction
Pteridines blood
Biopterins analogs & derivatives
Monocytes drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0263-6484
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell biochemistry and function
- Publication Type :
- Academic Journal
- Accession number :
- 3409479
- Full Text :
- https://doi.org/10.1002/cbf.290060307