Nucleotide sequence of the human theta 1-globin gene.

We have cloned and sequenced the human theta 1-globin gene. The nucleotide sequence and organization of the human theta 1 gene (exons, introns, promoter, and polyadenylation signals) are similar to those reported for the orangutan theta 1-globin gene. If these genes are functional, the sequences of their theta 1-globin chains would differ by only one amino acid residue (at position 137).