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Juvenile idiopathic arthritis in Harlequin ichthyosis, a rare combination or the clinical spectrum of the disease? Report of a child treated with etanercept and review of the literature.
- Source :
-
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2021 Jun 03; Vol. 19 (1), pp. 80. Date of Electronic Publication: 2021 Jun 03. - Publication Year :
- 2021
-
Abstract
- Background: Harlequin ichthyosis (HI) is the most severe phenotype of autosomal recessive congenital ichthyosis. Juvenile Idiopathic Arthritis (JIA) represents a heterogenous group of disorders all sharing the clinical manifestation of chronic arthritis. Association of HI and chronic arthritis has been reported in few cases.<br />Case Presentation: We report the case of a child with HI who developed a severe form of chronic polyarthritis during the first years of life, treated with repeated multiple joint injections, methotrexate and etanercept with good response and without any adverse events.<br />Conclusion: The reported case and the literature review highlighted the presence of a peculiar severe seronegative polyarthritis with early onset in a series of patients with HI, suggesting that polyarthritis may be a specific manifestation of HI, rather than a rare combination of two separate conditions.
Details
- Language :
- English
- ISSN :
- 1546-0096
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric rheumatology online journal
- Publication Type :
- Academic Journal
- Accession number :
- 34082764
- Full Text :
- https://doi.org/10.1186/s12969-021-00571-9