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Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines.
- Source :
-
ACS central science [ACS Cent Sci] 2021 May 26; Vol. 7 (5), pp. 757-767. Date of Electronic Publication: 2021 Apr 19. - Publication Year :
- 2021
-
Abstract
- The development of recombinant COVID-19 vaccines has resulted from scientific progress made at an unprecedented speed during 2020. The recombinant spike glycoprotein monomer, its trimer, and its recombinant receptor-binding domain (RBD) induce a potent anti-RBD neutralizing antibody response in animals. In COVID-19 convalescent sera, there is a good correlation between the antibody response and potent neutralization. In this review, we summarize with a critical view the molecular aspects associated with the interaction of SARS-CoV-2 RBD with its receptor in human cells, the angiotensin-converting enzyme 2 (ACE2), the epitopes involved in the neutralizing activity, and the impact of virus mutations thereof. Recent trends in RBD-based vaccines are analyzed, providing detailed insights into the role of antigen display and multivalence in the immune response of vaccines under development.<br />Competing Interests: The authors declare the following competing financial interest(s): Y.V.-B., D.S.-M, S.F., L.R., B.S.-R., K.L., D.G.-R., D.G.R., and V.V.B. are co-inventors on provisional SARS-CoV-2 vaccine patents including results covered here.<br /> (© 2021 The Authors. Published by American Chemical Society.)
Details
- Language :
- English
- ISSN :
- 2374-7943
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS central science
- Publication Type :
- Academic Journal
- Accession number :
- 34075345
- Full Text :
- https://doi.org/10.1021/acscentsci.1c00216