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Effects of Anthocyanins on Vascular Health.
- Source :
-
Biomolecules [Biomolecules] 2021 May 30; Vol. 11 (6). Date of Electronic Publication: 2021 May 30. - Publication Year :
- 2021
-
Abstract
- Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits and vegetables has well-known health benefits, especially due to its polyphenolic components. Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. The present review aims to give a current overview of the mechanisms involved in the vascular protective effect of anthocyanins from the human diet, considering epidemiological data, in vitro and in vivo preclinical research, clinical observational, retrospective, intervention and randomized studies, dietary and biomarker studies, and discussing preventive benefits of anthocyanins and future research directions.
- Subjects :
- Anthocyanins chemistry
Anthocyanins metabolism
Atherosclerosis metabolism
Atherosclerosis mortality
Dyslipidemias metabolism
Dyslipidemias mortality
Humans
Plaque, Atherosclerotic metabolism
Plaque, Atherosclerotic mortality
Anthocyanins therapeutic use
Atherosclerosis drug therapy
Dyslipidemias drug therapy
Endothelium, Vascular metabolism
Oxidative Stress drug effects
Plaque, Atherosclerotic drug therapy
Vascular Stiffness drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 34070757
- Full Text :
- https://doi.org/10.3390/biom11060811