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α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 May 10; Vol. 26 (9). Date of Electronic Publication: 2021 May 10. - Publication Year :
- 2021
-
Abstract
- α-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone 5 showed superior antitumor activity in vivo with both oral and intraperitoneal administration at 3 mg/kg. Cell-based mechanism of action studies demonstrated that 5 induced cell accumulation at sub-G1 and G2/M phases without interfering with microtubule polymerization. Furthermore, several cancer cell growth-related proteins were identified by using chalcone 5 as a bait for the affinity purification of binding proteins.
- Subjects :
- Animals
Cell Cycle drug effects
Cell Line, Tumor
Cell Proliferation drug effects
Chalcones chemistry
Docetaxel pharmacology
Humans
Male
Mice, SCID
Taxoids pharmacology
Xenograft Model Antitumor Assays
Mice
Antineoplastic Agents pharmacology
Chalcones pharmacology
Prostatic Neoplasms pathology
Receptors, Androgen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 34068627
- Full Text :
- https://doi.org/10.3390/molecules26092812