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Biological Activity of Selected Natural and Synthetic Terpenoid Lactones.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 May 10; Vol. 22 (9). Date of Electronic Publication: 2021 May 10. - Publication Year :
- 2021
-
Abstract
- Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by chemical synthesis. Terpenoids possessing lactone moieties are known for their cytotoxic, anti-inflammatory, antimicrobial, anticancer, and antimalarial activities. Moreover, one terpenoid lactone, artemisinin, is used as a drug against malaria. Because of these abilities, there is constant interest in new terpenoid lactones that are both isolated and synthesized, and their biological activities have been verified. In some cases, the activity of the terpenoid lactone is specifically connected to the lactone moiety. Recent works have revealed that new terpenoid lactones can demonstrate such functions and are thus considered to be potential active agents against many diseases.
- Subjects :
- Anti-Inflammatory Agents chemical synthesis
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents therapeutic use
Antimalarials chemical synthesis
Antimalarials chemistry
Antimalarials therapeutic use
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Artemisinins chemical synthesis
Artemisinins therapeutic use
Humans
Lactones chemical synthesis
Lactones therapeutic use
Plant Extracts chemistry
Plant Extracts therapeutic use
Sesquiterpenes chemical synthesis
Sesquiterpenes therapeutic use
Terpenes chemical synthesis
Terpenes therapeutic use
Artemisinins chemistry
Lactones chemistry
Sesquiterpenes chemistry
Terpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34068609
- Full Text :
- https://doi.org/10.3390/ijms22095036