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Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 May 08; Vol. 22 (9). Date of Electronic Publication: 2021 May 08. - Publication Year :
- 2021
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Abstract
- Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.
- Subjects :
- Animals
Anti-Inflammatory Agents pharmacology
Body Weight drug effects
Cardiotonic Agents pharmacology
Female
Heart Ventricles drug effects
Heart Ventricles pathology
Heart Ventricles physiopathology
Hemodynamics drug effects
Hypertension, Malignant enzymology
Hypertension, Malignant pathology
Hypertension, Malignant physiopathology
Inflammation complications
Inflammation drug therapy
Myocardium pathology
NG-Nitroarginine Methyl Ester chemistry
NG-Nitroarginine Methyl Ester pharmacology
Organ Size drug effects
Oxidation-Reduction
Rats, Inbred SHR
Resveratrol chemistry
Resveratrol pharmacology
Thiobarbituric Acid Reactive Substances metabolism
bcl-2-Associated X Protein metabolism
Rats
Anti-Inflammatory Agents therapeutic use
Antioxidants therapeutic use
Apoptosis drug effects
Cardiotonic Agents therapeutic use
Hypertension, Malignant drug therapy
Resveratrol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34066865
- Full Text :
- https://doi.org/10.3390/ijms22095006