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Identification of Hypertension Subgroups through Topological Analysis of Symptom-Based Patient Similarity.

Authors :
Wang YF
Wang JJ
Peng W
Ren YH
Gao C
Li YL
Wang R
Wang XF
Han SJ
Lyu JY
Huan JM
Chen C
Wang HY
Shu ZX
Zhou XZ
Li W
Source :
Chinese journal of integrative medicine [Chin J Integr Med] 2021 Sep; Vol. 27 (9), pp. 656-665. Date of Electronic Publication: 2021 May 31.
Publication Year :
2021

Abstract

Objective: To obtain the subtypes of the clinical hypertension population based on symptoms and to explore the relationship between hypertension and comorbidities.<br />Methods: The data set was collected from the Chinese medicine (CM) electronic medical records of 33,458 hypertension inpatients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between July 2014 and May 2017. Then, a hypertension disease comorbidity network (HDCN) was built to investigate the complicated associations between hypertension and their comorbidities. Moreover, a hypertension patient similarity network (HPSN) was constructed with patients' shared symptoms, and 7 main hypertension patient subgroups were identified from HPSN with a community detection method to exhibit the characteristics of clinical phenotypes and molecular mechanisms. In addition, the significant symptoms, diseases, CM syndromes and pathways of each main patient subgroup were obtained by enrichment analysis.<br />Results: The significant symptoms and diseases of these patient subgroups were associated with different damaged target organs of hypertension. Additionally, the specific phenotypic features (symptoms, diseases, and CM syndromes) were consistent with specific molecular features (pathways) in the same patient subgroup.<br />Conclusion: The utility and comprehensiveness of disease classification based on community detection of patient networks using shared CM symptom phenotypes showed the importance of hypertension patient subgroups.<br /> (© 2021. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1672-0415
Volume :
27
Issue :
9
Database :
MEDLINE
Journal :
Chinese journal of integrative medicine
Publication Type :
Academic Journal
Accession number :
34060025
Full Text :
https://doi.org/10.1007/s11655-021-3336-3