Assay dependence of long-term kinetics of SARS-CoV-2 antibodies.

Authors :: Schallier A
De Baets S
De Bruyne D
Dauwe K
Herpol M
Couck P
Source :: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2021 Aug; Vol. 100 (4), pp. 115403. Date of Electronic Publication: 2021 Apr 22.
Publication Year :: 2021
Abstract: Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared 4 different serology assays in convalescents up to 7 months post-infection. Both Abbott assays showed a significative decrease of IgG antibodies over time. Whereas the Elecsys Anti‑SARS‑CoV‑2 N assay (Roche) initially showed a significant increase, antibody titers significantly decreased at the latest timepoint. Although not significant, the Elecsys Anti‑SARS‑CoV‑2 S assay (Roche) showed tendency towards increasing titers overtime. Our data showed that results of SARS-CoV-2 serology should be interpreted with caution.<br />Competing Interests: Declaration of competing interest Authors have no competing interests to declare<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)