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Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis.
- Source :
-
Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 461-473. Date of Electronic Publication: 2021 May 31. - Publication Year :
- 2021
-
Abstract
- Periodontitis induced by bacteria especially Porphyromonas gingivalis (P. gingivalis) is the most prevalent microbial disease worldwide and is a significant risk factor for systemic diseases such as rheumatoid arthritis (RA). RA and periodontitis share similar clinical and pathologic features. Moreover, the prevalence of RA is much higher in patients with periodontitis than in those without periodontitis. To explore the immunologic mechanism of periodontitis involved in RA, we established a mouse model of periodontitis and then induced RA. According to the results of paw thickness, arthritis clinical score, arthritis incidence, microscopic lesion using H&E staining, and micro-CT analysis, periodontitis induced by P. gingivalis promoted the occurrence and development of collagen-induced arthritis (CIA) in mice. Furthermore, periodontitis enhanced the frequency of CD19 <superscript>+</superscript> B cells, Th17, Treg, gMDSCs, and mMDSCs, whereas down-regulated IL-10 producing regulatory B cells (B10) in CIA mice preinduced for periodontitis with P. gingivalis. In vitro stimulation with splenic cells revealed that P. gingivalis directly enhanced differentiation of Th17, Treg, and mMDSCs but inhibited the process of B cell differentiation into B10 cells. Considering that adoptive transfer of B10 cells prevent RA development, our study, although preliminary, suggests that down-regulation of B10 cells may be the key mechanism that periodontitis promotes RA as the other main immune suppressive cells such as Treg and MDSCs are up-regulated other than down-regulated in group of P. gingivalis plus CIA.<br /> (©2021 Society for Leukocyte Biology.)
- Subjects :
- Animals
Antigens, CD19 metabolism
Arthritis, Experimental immunology
Arthritis, Experimental microbiology
Arthritis, Rheumatoid diagnostic imaging
Disease Models, Animal
Down-Regulation
Inflammation pathology
Mice
Myeloid-Derived Suppressor Cells metabolism
Periodontitis diagnostic imaging
Periodontitis immunology
Porphyromonas gingivalis immunology
T-Lymphocytes, Regulatory immunology
Th17 Cells immunology
Arthritis, Rheumatoid immunology
Arthritis, Rheumatoid microbiology
Periodontitis microbiology
Porphyromonas gingivalis pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3673
- Volume :
- 110
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of leukocyte biology
- Publication Type :
- Academic Journal
- Accession number :
- 34057740
- Full Text :
- https://doi.org/10.1002/JLB.3MA0121-045R