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Upregulation of INF-γ, IL-6, and IL-8 expression during replication of turkey coronavirus in nonepithelial cells obtained from Meleagris gallopavo.
- Source :
-
Archives of virology [Arch Virol] 2021 Aug; Vol. 166 (8), pp. 2285-2289. Date of Electronic Publication: 2021 May 31. - Publication Year :
- 2021
-
Abstract
- Mesenchymal stromal cells (MSCs) are considered multipotent progenitors with the capacity to differentiate into mesoderm-like cells in many species. The immunosuppressive properties of MSCs are important for downregulating inflammatory responses. Turkey coronavirus (TCoV) is the etiological agent of a poult mortality syndrome that affects intestinal epithelial cells. In this study, poult MSCs were isolated, characterized, and infected with TCoV after in vitro culture. The poult-derived MSCs showed fibroblast-like morphology and the ability to undergo differentiation into mesodermal-derived cells and to support virus replication. Infection with TCoV resulted in cytopathic effects and the loss of cell viability. TCoV antigens and new viral progeny were detected at high levels, as were transcripts of the pro-inflammatory factors INFγ, IL-6, and IL-8. These findings suggest that the cytokine storm phenomenon is not restricted to one genus of the family Coronaviridae and that MSCs cannot always balance the process.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
- Subjects :
- Animals
Cell Differentiation
Cell Survival
Cytopathogenic Effect, Viral
Interferon-gamma metabolism
Interleukin-6 metabolism
Interleukin-8 metabolism
Mesenchymal Stem Cells cytology
Mesenchymal Stem Cells metabolism
Mesenchymal Stem Cells virology
Turkeys
Up-Regulation
Coronavirus, Turkey physiology
Cytokines metabolism
Virus Replication
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 166
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 34057608
- Full Text :
- https://doi.org/10.1007/s00705-021-05120-z