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Paper-Based Potentiometric Sensors for Nicotine Determination in Smokers' Sweat.

Authors :
Amr AEE
Kamel AH
Almehizia AA
Sayed AYA
Elsayed EA
Abd-Rabboh HSM
Source :
ACS omega [ACS Omega] 2021 Apr 22; Vol. 6 (17), pp. 11340-11347. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Publication Year :
2021

Abstract

Herein, we describe for the first time, the design and fabrication of a novel nicotine paper-based sensor, in which a miniaturized paper reference electrode is integrated for potentiometric measurements. The paper-based sensors were designed using printed wax barriers to define the electrochemical cell and the sample zones. The electrodes were based on the use of the ion association complexes of the nicotinium cation (Nic) with either tetraphenylborate (TPB) or 5-nitrobarbiturate (NB) counter anions as sensing materials for nicotine recognition. A poly (3,4 ethylenedioxythiophene)/poly-(styrene sulfonate) (PEDOT/PSS) conducting polymer was used as an ion-to-electron transducer. The performance characteristics of the proposed sensors were evaluated and it revealed a rapid and stable response with a Nernstian slope of 55.2 ± 0.3 and 51.2 ± 0.6 mV/decade over the linear range of 1.0 × 10 <superscript>-5</superscript> to 1.0 × 10 <superscript>-2</superscript> M and detection limits of 6.0 and 8.0 μM for [Nic/TPB] and [Nic/NB], respectively. The sensors revealed a constant response over the pH range 3.5-6.5. The designed sensors provided a portable, inexpensive, and disposable way of measuring trace levels of nicotine coming from different cigarettes and in the collected human sweat of heavy smokers. All results were compared favorably with those obtained by the standard gas chromatographic method.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2021 The Authors. Published by American Chemical Society.)

Details

Language :
English
ISSN :
2470-1343
Volume :
6
Issue :
17
Database :
MEDLINE
Journal :
ACS omega
Publication Type :
Academic Journal
Accession number :
34056289
Full Text :
https://doi.org/10.1021/acsomega.1c00301