Back to Search
Start Over
Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2022 Nov; Vol. 106 (11), pp. 1542-1548. Date of Electronic Publication: 2021 May 26. - Publication Year :
- 2022
-
Abstract
- Aims: To identify single-nucleotide polymorphisms (SNPs) associated with central serous chorioretinopathy (CSCR) by a systematic review and meta-analysis, and to compare the association profiles between CSCR, neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).<br />Methods: We searched the EMBASE, PubMed and Web of Science for genetic studies of CSCR from the starting dates of the databases to 12 September 2020. We then performed meta-analyses on all SNPs reported by more than two studies and calculated the pooled OR and 95% CIs. We also conducted sensitivity analysis and adopted the funnel plot to assess potential publication bias.<br />Results: Totally 415 publications were reviewed, among them 10 were eligible for meta-analysis. We found 10 SNPs that have been reported at least twice. Meta-analysis and sensitivity analysis confirmed significant associations between CSCR and six SNPs in three genes, namely age-related maculopathy susceptibility 2 ( ARMS2 ) (rs10490924, OR=1.37; p=0.00064), complement factor H ( CFH ) (rs800292, OR=1.44; p=7.80×10 <superscript>-5</superscript> ; rs1061170, OR=1.34; p=0.0028; rs1329428, OR=1.40; p=0.012; and rs2284664, OR=1.36; p=0.0089) and tumour necrosis factor receptor superfamily, member 10a ( TNFRSF10A ) (rs13278062, OR=1.34; p=1.44×10 <superscript>-15</superscript> ). Among them, only TNFRSF10A rs13278062 showed the same trend of effect on CSCR, nAMD and PCV, while the SNPs in ARMS2 and CFH showed opposite trends in the SNP associations.<br />Conclusions: This study confirmed the associations of ARMS2 , CFH and TNFRSF10A with CSCR, and revealed that ARMS2 , CFH and TNFRSF10A may affect different phenotypic expressions of CSCR, nAMD and PCV.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Humans
Complement Factor H genetics
Complement Factor H metabolism
Fluorescein Angiography
Genetic Predisposition to Disease
Genotype
Polymorphism, Single Nucleotide
Receptors, TNF-Related Apoptosis-Inducing Ligand genetics
Central Serous Chorioretinopathy diagnosis
Central Serous Chorioretinopathy genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 106
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 34039561
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2021-318953