Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.

Authors :: Arzika AM
Maliki R
Abdou A
Mankara AK
Harouna AN
Cook C
Hinterwirth A
Worden L
Zhong L
Chen C
Ruder K
Zhou Z
Lebas E
O'Brien KS
Oldenburg CE
Le V
Arnold BF
Porco TC
Keenan JD
Lietman TM
Doan T
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. 1292-1295.
Publication Year :: 2021
Abstract: We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.<br />Clinical Trials Registration: NCT02047981.<br /> (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)

Subjects :: Child, Preschool
Drug Resistance, Bacterial genetics
Humans
Macrolides pharmacology
Mass Drug Administration
Anti-Bacterial Agents therapeutic use
Azithromycin pharmacology

Language :: English
ISSN :: 1537-6591
Volume :: 73
Issue :: 7
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 34037753
Full Text :: https://doi.org/10.1093/cid/ciab485

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