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Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks' gestation: a retrospective cohort study.

Authors :
Rustogi D
Synnes A
Alshaikh B
Hasan S
Drolet C
Masse E
Murthy P
Shah PS
Yusuf K
Source :
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Jun; Vol. 41 (6), pp. 1313-1321. Date of Electronic Publication: 2021 May 25.
Publication Year :
2021

Abstract

Objective: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants &lt;29 weeks&#39; gestation at 18-24 months of corrected age.&lt;br /&gt;Study Design: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of &lt;70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes.&lt;br /&gt;Results: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00-2.54).&lt;br /&gt;Conclusions: Risk of NDI was similar between LGA and AGA infants.

Details

Language :
English
ISSN :
1476-5543
Volume :
41
Issue :
6
Database :
MEDLINE
Journal :
Journal of perinatology : official journal of the California Perinatal Association
Publication Type :
Academic Journal
Accession number :
34035448
Full Text :
https://doi.org/10.1038/s41372-021-01080-z