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Nanomedicine-based delivery strategies for nucleic acid gene inhibitors in inflammatory diseases.
- Source :
-
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2021 Aug; Vol. 175, pp. 113809. Date of Electronic Publication: 2021 May 24. - Publication Year :
- 2021
-
Abstract
- Thanks to their abilities to modulate the expression of virtually any genes, RNA therapeutics have attracted considerable research efforts. Among the strategies focusing on nucleic acid gene inhibitors, antisense oligonucleotides and small interfering RNAs have reached advanced clinical trial phases with several of them having recently been marketed. These successes were obtained by overcoming stability and cellular delivery issues using either chemically modified nucleic acids or nanoparticles. As nucleic acid gene inhibitors are promising strategies to treat inflammatory diseases, this review focuses on the barriers, from manufacturing issues to cellular/subcellular delivery, that still need to be overcome to deliver the nucleic acids to sites of inflammation other than the liver. Furthermore, key examples of applications in rheumatoid arthritis, inflammatory bowel, and lung diseases are presented as case studies of systemic, oral, and lung nucleic acid delivery.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents therapeutic use
Drug Delivery Systems methods
Genes drug effects
Humans
Inflammation genetics
Nucleic Acids therapeutic use
Oligodeoxyribonucleotides, Antisense administration & dosage
Oligodeoxyribonucleotides, Antisense therapeutic use
RNA, Small Interfering administration & dosage
RNA, Small Interfering therapeutic use
Inflammation drug therapy
Nanomedicine methods
Nanoparticle Drug Delivery System
Nucleic Acids administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8294
- Volume :
- 175
- Database :
- MEDLINE
- Journal :
- Advanced drug delivery reviews
- Publication Type :
- Academic Journal
- Accession number :
- 34033819
- Full Text :
- https://doi.org/10.1016/j.addr.2021.05.019