NMDARs in prefrontal cortex - Regulation of synaptic transmission and plasticity.

Authors :: Banks PJ
Bashir ZI
Source :: Neuropharmacology [Neuropharmacology] 2021 Jul 01; Vol. 192, pp. 108614. Date of Electronic Publication: 2021 May 20.
Publication Year :: 2021
Abstract: In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.<br /> (Copyright © 2021. Published by Elsevier Ltd.)

Subjects :: Animals
Humans
Long-Term Potentiation physiology
Neuronal Plasticity physiology
Prefrontal Cortex physiology
Receptors, N-Methyl-D-Aspartate physiology
Synaptic Transmission physiology

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